LDL and Heart Disease

Layne discusses the critical role of LDL cholesterol in heart disease, emphasizing its ability to penetrate the endothelium and cause inflammation. He highlights the significance of lifetime exposure to LDL, supported by Mendelian randomization studies, which reveal a strong correlation between elevated LDL levels and heart disease risk. This evidence challenges previous beliefs about cholesterol ratios and underscores the need to reconsider how we view dietary fats and their impact on cardiovascular health.