Creatine and Depression

A study reveals that creatine supplementation may enhance the effectiveness of SSRIs in women with major depressive disorder, potentially lowering the required dosage. Research indicates that creatine influences the phosphocreatine system in the forebrain, which is linked to NMDA receptors—key players in neuroplasticity. This connection suggests that creatine could facilitate positive mood changes by altering neural circuits, although many mechanisms remain to be fully understood.