How to Use Exercise to Improve Your Brain’s Health, Longevity & Performance

Grit & Perseverance

The anterior midcingulate cortex plays a crucial role in perseverance and grit, as highlighted by Andrew Huberman. He explains that spontaneous activity in this brain region is linked to the psychological phenomenon of grit, which involves leaning into challenges and persisting through difficulties 1. This activity is not just theoretical; it's supported by brain imaging studies showing increased anterior midcingulate cortex activity during effort estimation and exertion 2.

Activation of the anterior midcingulate cortex is associated with grit and with persistence.

--- Andrew Huberman

Huberman emphasizes that engaging in challenging activities can stimulate this brain area, enhancing one's ability to persevere and exert effort 2.

   

Memory & Exercise

Exercise significantly impacts the hippocampus, a brain region vital for learning and memory. Andrew Huberman discusses how osteocalcin, released during exercise, travels to the brain to promote neuron growth in the hippocampus, potentially enhancing memory capacity 3. This process is supported by the action of brain-derived neurotrophic factor (BDNF), which aids in neuron and blood vessel growth, contributing to improved memory and cognitive function 4.

Osteocalcin is released from the bones during exercise, travels to the brain, and encourages the growth of neurons and their connections within the hippocampus.

--- Andrew Huberman

Regular exercise can mitigate age-related hippocampal decline, underscoring its importance for maintaining cognitive health over time 3.