Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52

Fasting Protocols

Fasting protocols are a key component in enhancing longevity, as discussed by David Sinclair and Andrew Huberman. David emphasizes the importance of timing in eating, suggesting that skipping a meal at the start or end of the day can be beneficial. He shares his personal routine of skipping breakfast, consuming only a small amount of yogurt or olive oil to aid in supplement absorption, and relying on liquids throughout the day 1. Andrew highlights the concept of pulsing, where periods of nourishment are alternated with fasting, to stimulate cellular defenses and slow aging 2.

The mice that were given resveratrol every second day on a normal diet lived dramatically longer than any other group.

--- David Sinclair

This approach aligns with findings that intermittent fasting can extend lifespan and improve vitality 2.

   

Fasting and Autophagy

Fasting induces autophagy, a process crucial for cellular health and longevity. David Sinclair explains that fasting activates longevity genes, such as sirtuins, which protect against aging and disease by maintaining low insulin levels 3. This cellular rest allows for the reestablishment of the epigenome, slowing the biological clock. Andrew and David discuss the philosophical aspect of fasting, emphasizing that enjoyment of life is essential, and minor indulgences like a bit of yogurt or olive oil won't significantly disrupt fasting benefits 4.

If you don't enjoy life, what's the point?

--- David Sinclair

The key is to gradually adapt to fasting, allowing the body to adjust to new eating patterns without drastic changes 4.