Ketamine's Dual Action
Ketamine's effects on depression may stem from its interaction with both glutamate and opioid systems. Research indicates that the metabolite hydroxy nor ketamine specifically targets opioid receptors, suggesting a significant role in mood regulation. Blocking these receptors with naltrexone diminishes ketamine's antidepressant effects, highlighting the opioid system's critical involvement in its therapeutic properties.In this clip
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Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity | Huberman Lab Podcast
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