Ketamine's effects vary significantly based on how it's administered, with injections providing a more efficient delivery compared to oral or sublingual methods. When taken orally, only about 25% of ketamine reaches the bloodstream, while sublingual use yields about 35%. This means that to achieve the same brain activity as an injection, one would need to consume much higher doses in pill form. Understanding these differences is crucial, especially as more individuals access ketamine through legal channels outside clinical settings.
