THC and Anxiety
THC may initially relieve anxiety, but over time, increased use leads to diminished effects and even heightened anxiety. As the body adapts to frequent THC exposure, the receptors responsible for its effects become less responsive, requiring higher doses for the same relief. Surprisingly, even those who weren't initially depressed may experience increased depression as a consequence of cannabis use, making them four times more likely to develop chronic major depression.In this clip
From this podcast

Huberman Lab
The Effects of Cannabis (Marijuana) on the Brain & Body | Huberman Lab Podcast #92
Related Questions
What are the effects of long-term cannabis use on depression and anxiety as discussed in the episode The Effects of Cannabis (Marijuana) on the Brain & Body | Huberman Lab Podcast #92 and the clip THC and Anxiety?
Why does cannabis increase anxiety and depression as discussed in the episode The Effects of Cannabis (Marijuana) on the Brain & Body | Huberman Lab Podcast #92 and the clip THC and Anxiety?
What are the effects of long-term cannabis use on depression and anxiety?