Nicotine's Effects
Nicotine activates the sympathetic nervous system, enhancing alertness and physical readiness while simultaneously increasing heart rate and blood pressure. However, smoking and vaping can lead to reduced blood flow and even impact penile girth due to damage to endothelial tissue. Interestingly, alternative methods of nicotine ingestion may bypass some of these harmful effects, yet the reduction in blood flow remains a concern.In this clip
From this podcast

Huberman Lab
Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping | Huberman Lab Podcast #90
Related Questions
What are the effects of nicotine on the cardiovascular system?
What effect does nicotine have on blood vessels as discussed in the episode Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping | Huberman Lab Podcast #90 and the clip Nicotine's Effects?
How does nicotine affect the heart?