mTOR and Depression

A groundbreaking study reveals that combining Rapamycin, an mTOR blocker, with ketamine significantly alters treatment outcomes for those with treatment-resistant depression. While traditional ketamine treatment shows a mere 13% response rate, the addition of Rapamycin increases nonresponse rates to over 40%. This research hints at a deeper connection between microglial activity and stress-related disorders, paving the way for future studies to explore the longevity of antidepressant effects.