Longevity Through Fasting
Caloric restriction has been shown to significantly extend lifespan, as evidenced by studies on rats. Low insulin levels activate longevity genes known as sirtuins, which are crucial for cellular health. Interestingly, periods of hunger may trigger these protective mechanisms, suggesting that intermittent fasting could play a vital role in promoting longevity.In this clip
From this podcast

Huberman Lab
Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52
Related Questions
Can hunger promote longevity?
Can hunger promote longevity as discussed in the episode Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52 and the clip Longevity Through Fasting?
What does research say about eating fewer calories and longevity in relation to the episodes Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52 and Longevity Through Fasting?