Psilocybin and Neuroplasticity

Psilocybin may induce lasting structural changes in the brain, particularly through the growth of new dendritic spines, which could explain the relief from depression experienced by users. Research indicates that therapeutic doses in humans are significantly lower than those used in animal studies, yet both show dramatic changes in brain connectivity. A systematic review further explores the biological mechanisms of psychedelics, detailing how they alter neuronal excitability and contribute to neuroplasticity.