What type of acetylcholine is needed in the body for neuroplastic changes to take place?

For neuroplastic changes in the brain to take place, the release of acetylcholine from specific brain areas is crucial. Andrew Huberman notes that acetylcholine must be released from both the brain stem and the nucleus basalis, combined with epinephrine, to facilitate plasticity changes. This release acts as a spotlight, marking active neurons during heightened alertness, which are then primed for strengthening and change during periods of rest and sleep 1 2.