NAC protocol for colds

Andrew Huberman discussed using N-acetylcysteine (NAC) for both preventing and treating colds in an episode of the Huberman Lab. Here are the key points:

1. Dosage Recommendations:

   • As a preventative, 1200 mg per day, divided into two doses of 600 mg each.
   • For treatment during a cold, 900 mg three times daily (morning, late morning, and afternoon) is suggested, but avoid taking it close to bedtime to prevent sleep disruption 1 2.

2. Mechanism of Action:

   • NAC primarily works by increasing glutathione levels, which supports overall health and immune function 1.

3. Effectiveness:

   • Studies show a substantial reduction in cold and flu incidence in people taking NAC compared to those who don't. For example, one study showed that 25% of NAC users contracted influenza compared to 79% of the placebo group 1.
   • Long-term use also showed a reduced probability of contracting influenza 2.

4. Practical Experience:

   • Huberman found NAC to be a powerful mucolytic, helping to alleviate nasal congestion and sinus pressure effectively 2.

5. Considerations:

   • NAC is generally available over the counter in the US, but advice on usage should be personalized based on individual needs and consultation with a healthcare provider is recommended 1.

By adhering to these guidelines, NAC could be a valuable tool in your protocol for dealing with colds.