What are the differences in effects between EPA and DHA?

Andrew Huberman and Rhonda Patrick have discussed the different effects of EPA and DHA, two essential omega-3 fatty acids, extensively:

1. EPA (Eicosapentaenoic Acid):

   • Primarily known for its anti-inflammatory properties, EPA is often emphasized for its beneficial effects on mood and depression. Research indicates that high doses of EPA (around 1,000 to 2,000 mg per day) can improve mood and potentially reduce the need for antidepressants 1 2. EPA is crucial in reducing inflammation and has shown effectiveness in mitigating depressive symptoms 3.
     
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     EPA and Mental Health
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2. DHA (Docosahexaenoic Acid):

   • DHA is essential for brain development and cognitive function. It's particularly crucial in prenatal and early childhood stages for brain health. Beyond early development, DHA supports overall cognitive function and has a role in maintaining attention. For instance, surpassing a threshold level of 300 mg of DHA per day is linked to improved attention, especially when combined with sufficient EPA intake 4 3.

In summary, EPA is more focused on mood regulation and reducing inflammation, which can alleviate symptoms of depression. DHA, on the other hand, is critical for brain development and cognitive functions, especially attention and brain health in the early life stages.