What are the DORAs?


The term "DORAs" stands for dual orexin receptor antagonists. These are a class of drugs used primarily for the treatment of insomnia. Orexin, also known as hypocretin, is a neurotransmitter involved in regulating arousal, wakefulness, and appetite. The deficiency of orexin is notably linked to narcolepsy, a disorder characterized by excessive daytime sleepiness and sudden sleep attacks. DORAs work by antagonizing the orexin receptors, thereby dampening the orexin system's ability to keep the brain awake, which can help facilitate sleep in people suffering from insomnia 1 .

Orexin and Sleep

Matthew explains how orexin, a crucial brain chemical, affects wakefulness and feeding behaviors. The deficiency of orexin in narcoleptic patients sheds light on the connection between orexin and sleep disorders like insomnia.

Huberman Lab

Dr. Matthew Walker: Protocols to Improve Your Sleep | Huberman Lab Guest Series