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  • NAC

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    N-Acetylcysteine (NAC) has been discussed by with regards to its effectiveness as a potential treatment and preventative measure for cold and flu. In a particular study cited, around 80% of participants who did not take NAC contracted influenza, compared to only 25% in the group that took NAC, which is a significant difference. NAC works by increasing levels of glutathione and was available over the counter in the US as of the recording date of the episode 1.

    He highlights that in his personal experience, he took NAC as a decongestant at a dosage of 900 milligrams three times per day when he had a cold and found it effective. However, he also mentions that it had the side effect of disrupting his sleep if taken too close to bedtime due to increased mucus flow 2.

    Regarding the debate about NAC being removed from over-the-counter sales, notes it was due to supplement companies making unsupported claims, such as for hangover treatment, which led to regulatory scrutiny. Subsequent advocacy may have played a role in it still being available for purchase 1.

    emphasizes that while he shares his personal experiences and that of specific studies, using NAC should be a personal decision, and one should also consider other more traditional methods such as proper nutrition, rest, and hydration to treat cold or flu symptoms 1.

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  • Tongkat

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    Tongkat Ali, also known as Longjack or by its botanical name Eurycoma longifolia, is a supplement that has discussed for its potential effects on hormone levels and libido. Here are some key insights about Tongkat Ali from the :

    • Potential Benefits: It may help to increase free testosterone by reducing sex hormone-binding globulin (SHBG) and can increase libido in both men and women. It also might slightly increase DHEA levels and be especially effective at lowering SHBG in individuals with high levels 1 2 3.

    • Dosage: Recommended doses range from 200 to 600 milligrams per day, but can vary up to 1200 milligrams, depending on individual factors such as body size or starting hormone levels. It's important to find the minimal effective dose for you and take into account the standardization of Tongkat Ali supplements, specifically their eurycomanone content 4 5.

    • Effect on Blood Work: Blood work results have shown that Tongkat Ali can cause an increase in free testosterone and a slight increase in luteinizing hormone in some individuals 3.

    • Cycling: While some supplements need to be cycled, mentions that Tongkat Ali typically does not require cycling. However, one suggestion for safe cycling mentioned by guest Kyle Gillett was an eleven months on, one month off cycle 1.

    • Timing: It's best taken early in the day as it can have a mild stimulant effect 5.

    • Sources: The Indonesian variety of Tongkat Ali is believed to be the most effective, particularly for its libido-enhancing effects 2.

    • Considerations: As with any supplement, it's essential to monitor hormone levels and consult with your doctor. Blood work and subjective measures should guide usage and evaluate safety and effectiveness 3.

    Always consult with a healthcare professional before adding any new supplement to your regimen to assess potential benefits and risks based on your individual health context.

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  • What are the effects of Tongkat Ali?

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    Tongkat Ali is associated with a number of effects, as per the discussions on the :

    1. Libido Enhancement: It can increase libido in both men and women; the Indonesian variety is reported to be highly effective 1.

    2. Testosterone Increase: It may reduce sex hormone-binding globulin (SHBG), thereby increasing free testosterone levels, which can enhance libido and other parameters associated with increased androgens 2 3.

    3. Hormone Impact: There are reports of slight increases in luteinizing hormone and DHEA levels. With high SHBG levels, Tongkat Ali shows more profound effects. At normal SHBG levels, it still can increase total and free testosterone 4.

    4. Mechanisms of Action: Tongkat Ali also acts on aromatase weakly, potentially reducing estrogen, and may modulate estrogen receptors, supporting a decrease in negative feedback inhibition of estradiol and an increase in testosterone 5.

    5. Potential Fertility Aid: While direct evidence linking Tongkat Ali to improved sperm quality is limited, increased androgens from supplementation may support spermatogenesis 3.

    6. Endocrine Alterations: Altering free androgens or estrogens can influence the binding proteins that bind to thyroid hormones, slightly modifying thyroid hormone profiles 4.

    7. Usage and Cycling: Dosage recommendations vary, but often range from 200 to 400 mg per day, typically taken early in the day due to its mild stimulant effect. Some individuals may need to cycle Tongkat Ali, potentially following an eleven months on, one month off pattern, though this is debated 2 6.

    8. Subjective Experiences: Response to Tongkat Ali may vary widely among individuals. Some report substantial changes in libido and free testosterone levels, while others might not notice any effects. Broadly, the more deficient a person is in testosterone or free testosterone, the more pronounced the effects of Tongkat Ali might be 2.

    Before adding Tongkat Ali or any supplement to your routine, it's strongly recommended to consult with a healthcare professional and conduct blood work to assess its impacts based on personal health status.

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  • Fagdojia

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    The term "Fagdojia" appears to be a typographical error, which you may have meant to be "Fadogia Agrestis." Fadogia Agrestis is a herbal supplement that has been discussed on the . The effects of Fadogia Agrestis include:

    1. Increased Testosterone Production: It has the potential to increase testosterone levels by stimulating the release of luteinizing hormone, which is necessary for the production of testosterone in the testes 1 2 3.

    2. Potential Toxicity at High Dosages: Studies in rats have shown potential toxicity to testicular cells at very high dosages, so it is important to stay within recommended dosage ranges and to consider cycling the supplement 3.

    3. Cycling Recommendation: To potentially avoid adverse effects, it is often recommended to cycle the use of Fadogia Agrestis, such as three weeks on followed by one week off, especially because long-term safety has not been definitively established 2.

    4. Effects on Testicular Size: Some users have noticed an increase in testicular size and volume, although the significance and impact of this are not fully understood 1.

    5. Blood Tests for Monitoring: It is advisable to monitor effects through blood tests before and after integrating such supplements to assess their impact on hormone levels and overall health 3.

    It's important to consult with a healthcare professional before taking Fadogia Agrestis or any other supplement, particularly to ensure it is appropriate for your health status and to understand the potential risks and proper dosing.

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