I have a question about this episode Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52 and this Methylene Blue Insights What do other experts say about ingesting methylene blue for health purposes as discussed in the episode Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52?

In the episode featuring David Sinclair on the Huberman Lab, the topic of ingesting methylene blue is discussed briefly. Andrew Huberman raises concerns about the practice, which some people engage in, supposedly for potential lifespan-extending properties found in lower organisms. However, both Huberman and Sinclair express skepticism about its safety, noting potential side effects such as bodily staining. They compare it to other unconventional and potentially unsafe practices, like ingesting colloidal silver, warning against such actions without proper scientific backing 1.

The experts emphasize the importance of critical thinking and caution regarding unconventional health practices. While there may be initial findings in non-human studies, the translation of such practices to human health often lacks evidence and can pose risks 1.

Insights from other experts on methylene blue highlight its potential health benefits and applications. Dr. Craig Koniver MD, a guest on the Huberman Lab, discussed several aspects of methylene blue:

1. Cognitive Enhancement: Methylene blue is noted for cognitive-enhancing properties, acting as a mild MAOI, which allows neurotransmitters like serotonin to remain active longer in the brain. This can boost mood and mental clarity, leading to reports of improved brain function by users 1 2.

2. Mitochondrial Function: It enhances mitochondrial function and can improve oxygen uptake, which is beneficial for energy production. This could serve as a form of nutritional support for mitochondrial health, with some users taking it regularly for these benefits 2.

3. Potential Risks and Usage Recommendations: Although methylene blue can be taken orally and has been used in larger intravenous doses, care should be taken regarding dosage, as excessive or rapid administration can cause vein spasms. It's available both as a prescription and over-the-counter, which makes regulation of its use important 1 2.

4. Historical and Emerging Uses: Traditionally used for treating carbon monoxide poisoning, methylene blue has gained interest for its oxygenating properties. Additionally, during the COVID-19 pandemic, it was noted for reducing symptoms and converting tests to negative rapidly, although these claims require more scientific investigation 3.

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     Methylene Blue Insights

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     Mitochondrial Insights

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     Methylene Blue Insights

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While there are promising potential benefits, the need for caution and skepticism around unconventional health practices is emphasized due to lack of comprehensive clinical trials and understanding of long-term effects. Always consult with healthcare professionals before starting new supplements.