Vitamin d


Vitamin D plays a crucial role in various physiological processes, including immune function, metabolism, and brain health. It's essential to have sufficient vitamin D levels, yet many individuals may be deficient, especially those not getting adequate sunshine.

often emphasizes the importance of vitamin D as a preprohormone with functions extending beyond calcium absorption, including gene regulation and suppression of inflammation. The skin acts as an endocrine organ in synthesizing vitamin D from sun exposure, highlighting the importance of spending time outdoors or using vitamin D supplements when necessary 1.

High doses of vitamin D supplementation are generally not recommended due to potential health risks, such as gastric distress. The majority of physicians agree that supplementing with 1000 to 2000 IU of vitamin D per day is likely safe for most people 2. However, some may require higher doses for sufficient vitamin D levels, and individual needs can vary greatly, occasionally requiring dosages as high as 5000 to 10000 IU. It is underscored that testing vitamin D levels is the best way to determine appropriate supplementation levels for individual needs, especially for those with genetic variations that affect vitamin D metabolism 3 4.

Vitamin D Hormone

Rhonda and Andrew discuss the importance of vitamin D as a steroid hormone and its impact on gene expression. They also highlight how skin serves as an endocrine organ and the role of sun exposure in the activation of hormone production.

Huberman Lab

Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70

Hypercalcemia, a major concern with very high levels of vitamin D supplementation, is unlikely with normal doses such as 1000 to 5000 IUs daily, which for most people will be reasonably safe 5. Nevertheless, it's always safest to consult with a healthcare provider before starting any supplement regimen.