Is it beneficial to supplement with methylene blue?

Methylene blue may have cognitive and mitochondrial effects, but the evidence presented is preliminary, and it can carry important medication-related risks.

• 1. Nootropic use and dose: It is described as a cognitive stimulant/nootropic; one clinician suggests no more than about 10 mg in the morning and says his clinic combines it with caffeine and B vitamins. These are his practice-based suggestions, not established dosing guidance. 1
• 2. Mitochondria and oxygen: Methylene blue can shuttle electrons in mitochondria, which may help limit electron leakage and oxidative stress; another proposed effect is helping red blood cells take up oxygen. 2 3
• 3. Antiviral and mood claims: The clinician characterizes it as possibly antiviral and says its mild MAOI activity may influence serotonin and cognition. These are potential effects, not assured benefits. 4
• 4. Interactions and availability: Because of its MAOI activity, methylene blue can contribute to serotonin syndrome, a serious risk; caution is especially warranted with medications affecting serotonin. It is described as both a prescription drug and available in over-the-counter supplement forms. 5 6 7