Does high sodium deplete potassium?

Direct answer: High sodium intake is not described as directly depleting potassium. Sodium and potassium work closely together in kidney regulation and in maintaining the electrolyte balance needed for cellular signaling and muscle contraction; the effects depend on context, including diet and fluid intake. 1 2

• Sodium and potassium balance: Both electrolytes help maintain the electrical gradients cells need to function and muscles need to contract. 2
• Hyponatremia: It can occur when excessive water dilutes the sodium concentration in the blood—not only from having too little sodium overall. 3