Are there any side effects?

When considering the side effects of supplements for PCOS, particularly with regard to myo-inositol and metformin, some potential issues are important to be aware of.

1. Myo-inositol: Generally considered safe, but high doses might cause gastrointestinal issues like nausea or diarrhea. It's important for individuals to ensure they use the recommended dosages 1.

2. Metformin: Common side effects include gastrointestinal disturbances like nausea, vomiting, and diarrhea. Long-term use may affect vitamin B12 absorption, so monitoring levels can be beneficial 1.

3. Other Potential Issues: Both these interventions specifically address insulin resistance, which is common in PCOS. People considering these should be aware of their insulin and blood sugar levels, especially if combining them with other medications or supplements affecting insulin sensitivity 2.

As always, consulting with a healthcare provider before starting or changing a supplement regimen is recommended to tailor treatments to individual health needs and conditions.