TRT

TRT is intended to replace testosterone when levels are clinically low, but it can impair fertility and carries other risks.

• Normal-range testosterone: For men already in the 300–900 ng/dL range, testosterone may be used for augmentation rather than replacement; the discussion cautions against rushing into it, particularly when fertility matters. 1 2
• Fertility effects: Exogenous testosterone can suppress the body’s own testosterone production and sharply reduce sperm production; sperm quality may also be affected. 3 4
• Dose and frequency: A typical starting range described is 100–120 mg per week, divided into smaller, more frequent injections—often two or three times weekly. 5
• Risks and monitoring: Possible concerns include acne and other skin changes, hair loss, mood changes, cardiovascular and lipid issues, and fertility effects. Treatment should be monitored with appropriate clinical assessment and blood work. 6
• hCG: Clinicians sometimes use hCG alongside testosterone to help maintain sperm production, though the approach is not a guarantee of preserved fertility. 7