Do women have more testosterone in proportion to estrogen?

Women generally have a higher total level of testosterone compared to estrogen when measured in absolute amounts. This has been highlighted in discussions by Dr. Kyle Gillette, MD and Peter Attia on the Huberman Lab.

Key points include:

1. Testosterone Production: Most of the testosterone in premenopausal women originates from theca cells in the ovaries. While women produce significantly less total testosterone than men, this testosterone is still present in higher absolute amounts compared to estrogen, especially when considering free testosterone levels and the measurement units used (ng/dL for testosterone compared to pg/mL for estradiol) 1.

2. Ratios and Health: While society often perceives testosterone as a "male hormone," it is essential for women's health as well. In the context of health optimization and pathology prevention (e.g., osteoporosis and breast cancer), understanding both testosterone and estrogen levels is crucial 1.

3. Hormonal Dynamics: Testosterone and estrogen both play necessary roles in the body, and their relative proportions can influence various health outcomes, along with symptoms related to conditions such as PCOS (Polycystic Ovary Syndrome) 2.

In conclusion, while women have lower concentrations of testosterone than men, they can have higher absolute testosterone levels compared to estrogen, particularly when considered in their proper measurement contexts.