high cholesterol
Sources:
High cholesterol and its impacts are frequently discussed on the , including dietary considerations, medications, and health implications.
-
Dietary Cholesterol vs. Serum Cholesterol: There is significant debate regarding whether dietary cholesterol directly impacts serum cholesterol (LDL and HDL). Both and discuss this, differentiating between cholesterol and fat, and emphasizing the complexity of cholesterol's role in the body 1.
-
Cholesterol Medications: Different classes of drugs, such as statins and Ezetimibe, are commonly used to manage cholesterol levels. Statins work by reducing the body's cholesterol synthesis and increasing LDL receptor expression in the liver, while Ezetimibe blocks cholesterol absorption in the gut 2. The PCSK9 inhibitors are highlighted as the most potent, significantly reducing cholesterol levels by preventing the degradation of LDL receptors 3.
-
APOB and Atherosclerosis: APOB is identified as the key causative agent for atherosclerosis, rather than just focusing on LDL levels. Maintaining low APOB levels, ideally below 30 milligrams per deciliter, is crucial for reducing the risk of heart disease 4.
-
Overall Cholesterol Confusion: The literature on cholesterol can be conflicting, making it difficult to draw clear conclusions. While some argue that high LDL levels are detrimental and should be minimized, others note that factors such as CRP (C-reactive protein) are also critical markers of cardiovascular health 5.
Understanding these nuances and the role of cholesterol in overall health requires a personalized approach, often involving discussions with healthcare providers. For deeper insights, refer to episodes such as Using Play to Rewire & Improve Your Brain.
RELATED QUESTIONS-
