When is recommended to use NAC?

N-acetylcysteine (NAC) is recommended for several uses, primarily for its role as a mucolytic agent and for its potential in reducing the likelihood of contracting influenza. Andrew Huberman shared that he used NAC during a cold to help with congestion, taking 600 to 900 milligrams three times a day. He preferred using NAC over traditional decongestants due to its ability to reduce mucus build-up effectively without causing rebound congestion or other side effects associated with over-the-counter options 1.

Additionally, NAC may have a preventative role in reducing the incidence of influenza. A study highlighted by Dr. Huberman showed that regular intake of 600 milligrams twice daily reduced the probability of contracting influenza 2. He mentions that NAC is known to boost glutathione, which supports overall immune health 1.

While NAC is available over the counter, it's important to consider that taking it close to sleep might disrupt sleep due to increased mucus drainage. Andrew Huberman suggests taking NAC during the day for this reason 2.