According to the information presented on the Huberman Lab, creatine has been discussed as potentially beneficial in reducing fatigue in certain contexts. Andrew Huberman references a pilot study that looked at the effects of creatine on patients with traumatic brain injury (TBI), where supplementation significantly decreased the frequency of headache, dizziness, and a form of acute and chronic fatigue—not specifically chronic fatigue syndrome, but a general sense of bodily and even mental weakness 1. However, it is important to note that this context is quite specific, and the dosages used were higher than typical sports performance doses.

For general health and performance enhancement, consistent use of creatine over time is suggested to provide a 'buoyancy' in one's system, contributing to resilience when conditions aren't perfect. This speaks to the chronic, or slow modulatory effects, that creatine can have on mental and physical health with consistent supplementation 2.

Yet, it should be noted that discussing chronic fatigue as a medical condition may require a specialized approach, and therefore, the findings from the study on TBI patients cannot be directly applied to all cases of chronic fatigue without further evidence. Always consult a healthcare provider before beginning any new supplement regimen.