Why does she recommend Creatine?

Stacy Sims recommends creatine primarily for its significant benefits on brain, mood, and gut health in women of all ages 1. She highlights that creatine supports the phospho-creatine system in the brain, which is crucial for cognitive functions and mood regulation. This has been supported by various studies that link creatine to improvements in major depression and its augmentation of SSRI effectiveness in women 2 3. Moreover, Andrew Huberman mentions that creatine supplementation can lead to increased activity in the forebrain phospho-creatine system, influencing NMDA receptor function, which is important for neuroplasticity—potentially shifting mood from negative to positive 3.