Turkestrone
- RELATED QUESTIONS
What is Turkestrone?
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Turkestrone, also called Turkesterone, is a type of ecdysteroid, a group of hormones that play a role in growth and development. According to Kyle Gillett, these ecdysteroids are produced in places such as the adrenal glands and testes in men and in the ovaries and adrenal glands in women. After menopause, women continue to produce similar hormones from their adrenal glands. Turkestrone, when crossing the blood-brain barrier, can act as a GABA agonist, which can help improve sleep 1.
For a deeper understanding, you might want to explore the episode "Hormones and Sleep" from the , specifically involving the discussion between and Kyle Gillett.
RELATED QUESTIONSFadogia
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Fadogia agrestis is an herb known for its potential effects on hormone levels, particularly testosterone. According to , Fadogia agrestis may increase luteinizing hormone (LH), which then boosts testosterone and estrogen production in both males and females. It's typically taken in dosages of around 600 milligrams per day, with many users reporting elevated libido, sperm production, and hormone levels 1.
However, it's vital to follow dosage guidelines and consider cycling the supplement to avoid potential toxicity. Excessive doses have been linked to toxicity in testicular cells in animal studies, though such effects require very high dosages. A common recommendation is to take the supplement three weeks on, one week off, or eight weeks on, two weeks off 2 3.
Getting blood tests before and after starting Fadogia agrestis is essential to monitor its effects on hormone levels and ensure there are no adverse effects 2.
RELATED QUESTIONSList clips similar to "Hormones and Sleep"
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Here are clips related to "Hormones and Sleep" from the that might interest you:
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Hormones and Sleep
Kyle Gillett discusses the correlation between hormone optimization and sleep, including how growth hormone deficiency and progestogenic activity can affect sleep.
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Hormones and Sleep
explains the role of hormones in our sleep-wake cycle, including cortisol and melatonin.
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Sleep and Hormones
Gina Poe discusses sex differences in sleep and how hormones affect sleep efficiency and learning phases.
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Sleep and Hormones
Matt Walker discusses the impact of alcohol on growth hormone release during sleep and the effects of disrupted REM sleep on testosterone.
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Sleep and Weight
Matthew Walker explains how sleep impacts appetite-regulating hormones, leptin and ghrelin, affecting hunger levels and cravings for unhealthy foods.
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Growth Hormone Insights
Andrew and Matthew discuss the importance of growth hormone release during sleep, emphasizing the significance of deep sleep and sleep timing.
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These clips provide various insights into how hormones interact with sleep and overall health.
RELATED QUESTIONS-
Tongkat Ali
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Here are some clips from the discussing Tongkat Ali:
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Tongkat Ali for Libido
discusses how Tongkat Ali can increase libido by enhancing free testosterone and affecting sex hormone binding globulin. Reports indicate it might also improve sexual function in both men and women.
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Fertility and Hormones
Huberman explains that Tongkat Ali can support hormone levels without shutting down endogenous testosterone production, making it useful for both men and women aiming to optimize fertility.
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Tongkat Ali Dosage
Discusses appropriate dosages for Tongkat Ali, highlighting its benefits for libido and testosterone levels, and mentions that its effectiveness might vary depending on individual hormone levels.
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Tongkat Ali Cycle
Conversation with Kyle Gillett on whether Tongkat Ali needs to be cycled. Recommendations include an 11 months on, 1 month off cycle, or no cycling needed if combined with other supplements.
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Tongkat Ali Effects
Discussion on how Tongkat Ali increases free testosterone and DHEA, and its effects on sex hormone binding globulin (SHBG) and other hormones like luteinizing hormone.
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Tongkat Ali Mechanisms
Explores mechanisms of Tongkat Ali affecting aromatase and estrogen receptors, and its application for men and women, especially those with hormone imbalances.
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Fertility Supplements
Huberman talks about Tongkat Ali's use for increasing free testosterone, libido, and supporting hormone profiles in both men and women, especially for fertility optimization.
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RELATED QUESTIONS-
What are the health benefits of Tongkat Ali?
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Tongkat Ali, also known as Eurycoma longifolia or longjack, has several notable health benefits that have been discussed on the . These include:
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Increasing Free Testosterone: Tongkat Ali can increase free testosterone by reducing sex hormone binding globulin (SHBG), thereby making testosterone more available in the body [1].
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Improving Libido: The herb has been shown to enhance libido and sexual function in both men and women. Some reports and studies indicate significant improvements in sexual desire and performance [2 3].
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Supporting Fertility: Tongkat Ali helps optimize hormone levels without shutting down endogenous testosterone production, making it beneficial for both male and female fertility. It may improve spermatogenesis in men and hormonal balance in women [4 5].
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Enhancing Vitality and Reducing Stress: The herb is reported to increase feelings of vitality and reduce stress, potentially through both hormone and neural pathways. This includes boosting luteinizing hormone and possibly impacting the dopamine-related pathways [3 6].
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Potentially Managing Estrogen Levels: Tongkat Ali has weak aromatase inhibitory effects, which can slightly reduce estrogen levels. This could be beneficial for individuals with hormone imbalances, particularly women with high estrogen levels [6].
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No Need for Cycling: Generally, Tongkat Ali does not require cycling. However, as a precaution, some experts suggest an eleven months on, one month off regimen [5].
As with any supplement, it's crucial to consult with a healthcare provider before beginning use, especially to determine appropriate dosages and to monitor hormone levels and overall health.
RELATED QUESTIONS-
Are there any side effects of Tongkat Ali?
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Tongkat Ali is generally considered safe for most people when taken in appropriate dosages, but there are some potential side effects and considerations to keep in mind:
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Hormonal Effects: While Tongkat Ali is known to increase free testosterone and slightly increase luteinizing hormone (LH) and dehydroepiandrosterone (DHEA), these hormonal changes can potentially alter thyroid hormone profiles, leading to symptoms such as tachycardia (fast heart rate) or an "overly fight-or-flight" state due to increased thyroid hormone activity if not monitored properly 1.
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Sleep Disruption: Some users report that taking Tongkat Ali later in the day can inhibit sleep due to its mild stimulant effects. It's often recommended to take it earlier in the day to avoid such issues 2.
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Dosage and Standardization: The effects of Tongkat Ali can vary greatly depending on the dosage and the standardization of the active compounds in the supplement. It's important to check the uricominone content, the active pharmacological compound, to ensure efficacy. Higher standardization implies a more effective lower dose 2.
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Effective Dosage: It's advised to begin with the minimum effective dose, often starting around 200 milligrams and scaling up to 600 milligrams per day based on individual response and blood work 3.
Overall, while Tongkat Ali can provide various health benefits, it’s crucial to monitor its effects on your body, possibly through regular blood work, and to consult with a healthcare provider to adjust dosages appropriately.
RELATED QUESTIONS-
What are the detailed health risks?
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While Tongkat Ali is generally considered safe when taken within recommended dosages, there are some detailed health risks and considerations to bear in mind:
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Hormonal Effects: Tongkat Ali can impact the hormonal axis, including thyroid hormone profiles. It can potentially cause symptoms of tachycardia (rapid heartbeat) or an "overly fight-or-flight" state due to increased thyroid hormone activity 1.
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Disruption of Endogenous Production: Unlike hormone therapy, Tongkat Ali does not shut down endogenous hormone production. However, caution should still be taken to ensure that supplements do not contain unintended hormones, especially those derived from testicular extracts which might contain testosterone and affect the body's hormone production 2.
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Liver Function: Long-term use of Tongkat Ali should be monitored through regular blood work, including liver enzyme levels, as its impact over prolonged periods isn't fully studied 3.
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Potential Need for Cycling: Although continuous long-term use of Tongkat Ali typically doesn't require cycling, some experts suggest an "11 months on, 1 month off" cycle to be safe. This recommendation is partly due to its effects on aromatase and estrogen receptor modulation 1.
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Libido and Hormonal Shifts: Tongkat Ali has been shown to significantly increase libido and free testosterone by lowering sex hormone-binding globulin. These hormonal changes should be monitored, especially in individuals with existing hormone-related conditions 4.
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Reproductive Health: For those using hormonal supplements, there is a concern about the potential for unintended shutdown of sperm or egg production. However, Tongkat Ali does not appear to have this effect and may even enhance spermatogenesis due to an increase in androgen levels 2 5.
It's important to consult with a healthcare provider before beginning Tongkat Ali, especially for individuals with existing health conditions or those taking other medications. Monitoring through regular blood work and starting with the minimum effective dose is strongly recommended.
RELATED QUESTIONS-
Testosterone improvement
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Enhancing testosterone levels can be approached through various methods and supplements, as discussed on the :
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Hormone Replacement Therapy (TRT): For those with clinically low testosterone, hormone replacement therapy is an option. Dr. Kyle Gillett suggests that administering low doses more frequently (e.g., 100-120 mg per week split into two to three doses) can help maintain steady testosterone levels without the peaks and troughs that large doses can cause 1.
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Cold Exposure: Deliberate cold exposure, specifically targeting the groin area, has been proposed to potentially increase testosterone. The mechanisms hypothesized include increased blood flow to the testicles and rises in dopamine, which can trigger hormonal pathways involved in testosterone production. However, robust scientific evidence and controlled studies are lacking 2.
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Supplements:
- Tongkat Ali: This supplement may increase libido and free testosterone levels by lowering sex hormone-binding globulin (SHBG). Its benefits on spermatogenesis and overall reproductive health are also noted 3.
- Tribulus Terrestris: While its impact on overall testosterone levels is varied, some studies suggest it can enhance libido and increase bioavailable testosterone 4.
- Shilaji: Though not a top-tier option, Shilaji might improve sperm quality and cause slight increases in testosterone. It also has other benefits like boosting vitality and libido, likely due to its effects on follicle-stimulating hormone (FSH) 5.
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Lifestyle Factors:
- Sleep: Adequate and quality sleep is crucial. An additional 30-60 minutes per night can significantly benefit testosterone levels 5. Improving sleep posture and environment, as seen in the case of an athlete with sleep disturbances, can lead to notable boosts in testosterone levels 6.
- Exercise: Incorporating both resistance and cardiovascular training is essential. Overtraining should be avoided to prevent negative impacts on testosterone 5.
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Vitamin D and Boron: Ensuring optimal levels of Vitamin D (a steroid hormone) and Boron (especially for those with high SHBG) can help optimize testosterone levels 7.
By considering these methods and consulting healthcare professionals, individuals can make informed decisions to effectively manage and improve their testosterone levels.
RELATED QUESTIONS-
Which supplements work best?
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To improve testosterone levels, there are several supplements that recommends, based on various studies and expert insights:
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Tongkat Ali: Often known as Long Jack, Tongkat Ali helps upregulate several enzymes in the steroidogenesis cascade, which supports testosterone production. It's especially powerful for those on lower-carb diets or in caloric deficits. Dosages range from 300 to 1200 milligrams per day 1.
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Fadogia Agrestis: This supplement can be effective for individuals with lower luteinizing hormone (LH) levels. It helps increase LH, which is upstream of testosterone production. The recommended cycling is three weeks on, one week off, with typical dosages around 600 milligrams 2.
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Shilajit: While Shilajit offers minor benefits like improved sperm quality and slight testosterone increases, it's not a top supplement choice. It may increase vitality and libido, but its effects are modest compared to other options 3.
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Tribulus Terrestris: Used to boost libido and potentially increase free and bioavailable testosterone. Studies show varying results, but it may offer benefits for sexual desire and function, particularly in specific populations 4.
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Vitamin D3 and Boron: These are crucial for testosterone optimization. Vitamin D3 supports overall hormone health, and boron (5-12 mg per day) helps reduce sex hormone-binding globulin (SHBG), which can enhance free testosterone levels 5.
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Ashwagandha: Known for reducing cortisol levels, which indirectly helps increase testosterone. Cortisol and testosterone have an inverse relationship; lowering cortisol can support higher testosterone levels. However, it should be cycled, not taken for more than two weeks at high doses 5.
Implementing these supplements, alongside optimizing lifestyle factors such as sleep, nutrition, and exercise, can effectively enhance testosterone levels. Always consult a healthcare provider before starting any new supplement regimen.
RELATED QUESTIONS-
Brain fog
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Brain fog can result from several factors, and has addressed various causes and remedies:
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Hydration: Even slight dehydration can impair cognitive performance and create brain fog. Proper hydration can enhance focus and overall energy levels by triggering the sympathetic nervous system to increase alertness 1.
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Gut Health: A diverse gut microbiota is crucial for brain function. Dysbiosis (lack of diversity) can lead to brain fog. Consuming fermented foods to promote microbiota diversity can help maintain mental clarity. However, excessive intake of probiotics can also cause mental fog 2 3.
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Post-Exercise: Intense exercise can lead to brain fog due to rises in brain temperature, which decreases cognitive capacity. Managing body temperature and staying cool can help mitigate this effect 4.
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Diet and Supplements: L-tyrosine, a dietary supplement, can increase dopamine levels and improve mood and alertness. However, it may also cause brain fog if not taken appropriately or in excess 5.
Managing these factors through proper hydration, maintaining a healthy gut microbiome, regulating body temperature during and after exercise, and monitoring dietary supplements can help reduce brain fog. Always consider consulting a healthcare provider for personalized advice.
RELATED QUESTIONS-
Supplements to decrease brain fog
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Here are some supplements that recommends for decreasing brain fog:
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Ketone Supplements: Supplements that increase blood ketones, such as HVMN's Ketone IQ, can improve cognitive ability and focus. These supplements help even when you are not on a ketogenic diet. They can be beneficial for mental work and physical performance, providing more energy and reducing hunger 1 2.
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Nootropics: Customized nootropics from companies like Thesis can tailor supplements to your unique cognitive needs. They focus on different neural circuits for specific functions like focus and clarity, which can help improve cognitive work and reduce brain fog 1.
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Omega-3 Fatty Acids: Omega-3 supplements, especially those rich in EPA, support overall brain health and cognitive function. Ingesting one to three grams of EPA per day can improve focus, cognitive ability, and general brain health 3.
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L-Tyrosine: This supplement can increase dopamine levels, which can enhance mood and alertness. However, it should be used cautiously as it might cause a crash or even brain fog if not taken properly 4.
Maintaining gut health by ensuring microbiota diversity can also help mitigate brain fog. Regular consumption of fermented foods is beneficial for gut and brain health, but excessive intake of probiotics can lead to brain fog 2. Always consult a healthcare provider before starting any new supplement regimen.
RELATED QUESTIONS-
