What supplements aid in nerve transmission?


Several supplements can aid in nerve transmission and overall nerve health:

  1. Citrulline and Arginine: These supplements are involved in the nitric oxide pathway which helps in vasodilation, thereby aiding the transport of nutrients in and out of cells, which can have a performance-enhancing effect. However, they should be used cautiously by those prone to cold sores as they can exacerbate such conditions due to their effect on the Arginine pathway 1.

  2. Alpha GPC: This supplement acts as a cholinergic agonist, meaning it can enhance focus and alertness without being a stimulant. It's often used before physically or mentally demanding activities to boost performance 1.

  3. Acetyl L-carnitine: This supplement aids in improving mitochondrial metabolism and overall mitochondrial health. It's particularly noted for its potential disease-modifying properties in conditions like diabetic neuropathy, as evidenced by improvements in nerve conduction velocity 2.

  4. Alpha Lipoic Acid: Known for its role as a free radical scavenger and T-type calcium channel modulator, this supplement can be beneficial for neuropathic pain. However, it might impact heart rate during intense physical activity, so usage should be monitored 2.

  5. Vitamin C: Taking Vitamin C prophylactically before surgeries involving nerves can reduce the likelihood of developing certain nerve pain conditions post-surgery 2.

Each of these supplements has specific effects and potential benefits related to nerve function and health, but they also come with cautions or specific considerations depending on individual health conditions. Always consult with a healthcare professional before starting any new supplement regimen.

Non-Stimulant Performance Enhancers

Andy and Andrew discuss non-stimulant supplements that can enhance performance without disrupting sleep, including citrulline, beetroot, and Alpha GPC. They also touch on the use of these supplements in caloric restriction situations and caution against their use for those prone to cold sores.

Huberman Lab

Dr. Andy Galpin: Optimal Nutrition & Supplementation for Fitness | Huberman Lab Guest Series