Is nicotine use safe?


According to and , nicotine use, especially when derived from tobacco, poses various health concerns. Smoked nicotine is problematic for testosterone and estrogen levels and carries a risk of cardiovascular disease or neurodegenerative diseases like dementia when used in high doses for extended periods. It's a dose-dependent effect that can negatively impact hormone profiles 1.

Nicotine also has reinforcing effects due to the release of dopamine, which makes it difficult to quit despite the known risks such as increased rates of cancer, stroke, heart attack, and cognitive decline, as well as potential damage to endothelial cells, mouth cancers from dipping, nasal cancers from snuffing, and overall health deterioration 2.

Overall, while nicotine can improve alertness and focus in the short term, reliance on nicotine or nicotine-containing products for this purpose is not recommended due to the associated health risks 3. It's vital to approach nicotine use with caution and awareness of these potential consequences.

Hormone Optimization Don'ts

Kyle and Andrew discuss the negative effects of cannabis and nicotine on hormone levels. Smoking cannabis can decrease testosterone and increase prolactin, while smoked nicotine can harm both testosterone and estrogen levels.

Huberman Lab

Dr. Kyle Gillett: Tools for Hormone Optimization in Males | Huberman Lab Podcast 102