What is NAC?

N-acetylcysteine (NAC) is a supplement with several notable benefits, primarily as a precursor to glutathione, which is often referred to as the body’s master antioxidant. NAC plays a crucial role in reducing reactive oxygen and nitrogen species, which can accumulate during stress or infection, potentially aiding the body's response to illness 1.

Key Points about NAC:

• Mucolytic Properties: NAC is recognized for its ability to break down mucus, making it particularly useful for individuals with respiratory conditions like cystic fibrosis, as it helps clear mucus from the lungs 1.
• Cold and Flu Prevention: Some studies suggest that long-term NAC use may lower the likelihood of contracting influenza. In one study, only 25% of participants taking NAC contracted the flu compared to 79% in the placebo group 2.
• Dosage Recommendations: The typical dosage recommended when using NAC for colds or flu ranges from 600 to 1200 mg per day, often split into two doses 2.
• Personal Experience: Andrew Huberman has shared his own experience with NAC during a cold, noting its effectiveness in relieving sinus pressure without the drawbacks of common over-the-counter decongestants, which can lead to rebound congestion and other issues 3.
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    NAC for Flu Prevention

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Overall, NAC is a versatile supplement that supports antioxidant levels and respiratory health, making it relevant for those looking to bolster their immune defenses.

N-acetylcysteine (NAC) is generally well-tolerated; however, some side effects have been reported. Notably, these may include:

1. Gastrointestinal Issues: NAC can cause stomach upset, nausea, vomiting, and diarrhea, especially at higher doses 1.
2. Skin Reactions: Allergic skin reactions, although less common, can occur 1.
3. Headaches: Some individuals report headaches when taking NAC 1.
4. Hypersensitivity Reactions: In rare cases, NAC may provoke hypersensitivity reactions, including anaphylaxis in sensitive individuals 1.

Precautions

• Consult a Healthcare Provider: If considering NAC, it is advisable to consult a healthcare provider, particularly for individuals with asthma, as it may provoke bronchospasm 1.
• Dosage Monitoring: Starting with a lower dose can help mitigate side effects and assess individual tolerance.

Overall, while NAC presents potential benefits, awareness of these side effects is essential for safe usage.