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  • Guanfacine

  • Sources:

    Guanfacine is a non-stimulant medication primarily used to treat ADHD. It works by agonizing the alpha-2A receptor for norepinephrine, thereby increasing focus and reducing impulsivity and hyperactivity. Notably, it affects only the norepinephrine system, unlike other ADHD medications that ramp up both dopamine and norepinephrine 1.

    Key Points on Guanfacine:

    1. Mechanism:

      • It activates prefrontal cortical networks, enhancing executive function.
      • Acts as a fine-tuning agent for the neural circuits involved in attention and impulse control 2.

    2. Usage:

      • Approved for children aged 6-17 with ADHD.
      • Often prescribed in conjunction with other ADHD medications to mitigate side effects, though this raises concerns about polypharmacology 2.

    3. Benefits and Drawbacks:

      • A small subset of individuals (5-10%) experiences significant relief from ADHD symptoms.
      • Can cause sleepiness and lower blood pressure, which is why it isn't frequently prescribed 1.

    4. Critical Warning:

      • Guanfacine significantly reduces tolerance to alcohol. Even small amounts of alcohol can lead to serious health risks or potentially death 2.

    For more detailed insights, you can explore the full episode of the titled "Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects" .

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