How does weed affect your mood?


Cannabis, specifically its sativa varieties, generally tends to elevate mood, increase talkativeness, and promote a sense of focus and heightened importance on activities. This effect can be attributed to the activation of CB1 receptors in the prefrontal cortex and other brain circuits that reduce stress. However, some individuals might experience anxiety and paranoia regardless of the cannabis strain or the THC to CBD ratio. Interestingly, chronic use of cannabis (twice a week or more) can actually increase anxiety levels over time, according to studies referenced by 1 2.

Additionally, it's worth noting that while cannabis can lead to subjective effects perceived as creativity or an energetic mood boost, there are no reliable predictors for who will experience positive mood effects versus those who might experience increased anxiety or paranoia 3.

Cannabis Effects

Andrew explains the different effects of sativa and indica varieties of cannabis, with sativa varieties tending to elevate mood, increase focus, and make people talkative, while indica varieties tend to have a sedative effect. He also discusses the role of CB1 receptors in the brain and how they affect stress and limbic circuitry.

Huberman Lab

The Effects of Cannabis (Marijuana) on the Brain & Body | Huberman Lab Podcast #92

Furthermore, also points out that cannabis can have negative health effects, including an increased risk of developing major depression, severe anxiety, or psychosis later in life, particularly when used by younger individuals between 16 to 24 years old 4. These findings underline the importance of understanding both the potential positive mood effects and the negative mental health risks associated with cannabis use.