What does huberman discuss about ssri's and neuroplasticity?

Andrew Huberman has explored the relationship between SSRIs and neuroplasticity, highlighting several key points:

1. Mechanism of Action: SSRIs increase serotonin levels at the synapse, enhancing its efficacy. Although enhancement is immediate, relief from depression often takes weeks, indicating a complex mechanism beyond just serotonin increase 1.

2. Role in Neuroplasticity: SSRIs may promote neuroplasticity, allowing for the rewiring of neural circuits, which might explain the delay in therapeutic effects. This includes the generation of new neurons and reopening critical periods of plasticity, as observed in animal studies 1.

3. Comparison with Psychedelics: Huberman compares SSRIs with psychedelics like psilocybin, both of which may aid neuroplasticity differently. SSRIs work through serotonin modulation, while psychedelics might provide more direct neuroplastic benefits 2.

4. Impact on Neural Circuits: The relief from depression using SSRIs is likely due to their facilitative role in changing neural circuits through neuroplasticity rather than solely restoring serotonin levels 3.

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     1

     SSRIs and Neuroplasticity

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     2

     Depression and Neuroplasticity

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     3

     Serotonin and Depression

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These insights suggest that while SSRIs are often effective, their benefit might significantly arise from their ability to support neuroplasticity, which is foundational in improving mood and cognitive functions.