NAD

Nicotinamide adenine dinucleotide (NAD) has been a topic of discussion on the Huberman Lab, particularly its potential benefits and the various methods of supplementation. Here are some key insights:

1. NAD Supplementation:

   • Forms and Effects: NAD can be increased through various methods including intravenous infusions, oral NR (Nicotinamide Riboside), and sublingual NMN (Nicotinamide Mononucleotide). However, there is substantial variation in the efficacy and comfort of these methods. Andrew Huberman shares that NMN is no longer widely available due to FDA rulings but remains available for those who seek it out. He personally takes NR and NMN, noting increased energy levels without negative impacts on sleep 1.
   • Cost and Effectiveness: Intravenous NAD infusions are notably expensive, ranging from $300 to $1000 per session. The actual benefits, including potential lifespan extension, are still not well-substantiated by rigorous scientific data. It's a leap of faith but is being pursued based on the hope that increased NAD levels may offer longevity benefits 2.

2. Scientific and Practical Considerations:

   • Lifespan Research: Few molecules tested in rigorous longevity studies have shown significant extension of lifespan, indicating that the effectiveness of NAD supplementation specifically for longevity is uncertain. The Interventions Testing Program (ITP) has highlighted the incomplete nature of current research and underlines the need for more comprehensive testing 2.
   • Energy and Well-being: Despite the lack of conclusive evidence for lifespan extension, many, including Andrew Huberman, take NAD supplements for their perceived benefits in energy enhancement. This is a personal testimonial rather than a blanket endorsement, with an emphasis on how these supplements make users feel rather than expecting definitive longevity benefits 1.

Overall, while the promises of NAD supplementation are intriguing for both energy enhancement and potential longevity benefits, the comprehensive scientific validation is still pending. Users are advised to approach these supplements with cautious optimism, understanding the current limitations in evidence 2 3.