In one of Andrew‘s podcast he mentions how taking melatonin supplements will make it to the body stops producing its own. Can you explain that to me?

Andrew Huberman discusses how melatonin supplementation can affect the body's natural production and release of melatonin. While melatonin is naturally produced by the body and plays a critical role in regulating various biological functions, supplementation can disrupt these natural rhythms. The levels of melatonin in most supplements are typically much higher than what the body would naturally produce, leading to super physiological levels that might not align with the body's natural sleep-wake cycle or its seasonal adaptations 1 2.

Furthermore, when you supplement with melatonin, it alters the natural patterns and amounts of melatonin released throughout the year. This can have broader implications given the hormone's impact on cardiovascular health, immune function, and even reproductive health 2. Therefore, Dr. Huberman recommends being cautious with melatonin supplementation due to these potent effects, advocating for natural regulation of melatonin levels through lifestyle and environmental adjustments rather than long-term use of supplements 2.