Berberine

Andrew Huberman has discussed berberine extensively on the Huberman Lab podcast, explaining its significant effects on blood glucose regulation and comparing it with prescription drugs like metformin. Berberine is a compound derived from tree bark that can lower blood glucose levels effectively, sometimes leading to hypoglycemia if taken without carbohydrates 1. It activates the AMPK pathway, which is associated with fasting and reduced blood glucose 2.

People sometimes use berberine when they anticipate consuming large meals, particularly those high in carbohydrates, to mitigate the spike in blood glucose 3. However, it should be approached with caution, and when considering its use, one should start with the lowest effective dose to avoid adverse reactions 2.

Berberine also has been discussed regarding its other benefits, such as improving insulin sensitivity, lowering total cholesterol, and even having the unique property of eliminating canker sores upon direct contact 4.

Andrew Huberman has shared his personal experiences with the substance, noting its potential for causing headaches and dizziness when his blood sugar dropped too low, suggesting cautious use 2. Moreover, Dr. David Sinclair mentioned that berberine has a positive impact on energetics and metabolism, and while there has been a cautionary study in worms, berberine is considered safe in human clinical trials 5.

As always, it's recommended to discuss with a healthcare provider before using berberine or any other supplements, especially due to potential significant effects on blood glucose and overall health.