What is semaglutide

Semaglutide is a GLP-1 receptor agonist medication used to treat type 2 diabetes and obesity. It is marketed as Ozempic for diabetes and Wegovy for weight loss. 1 2

• Appetite and weight: It can reduce appetite through effects on brain circuits, including hypothalamic neurons; it may also activate gut mechanosensors that signal fullness. 3 4
• Other effects and side effects: It may improve insulin sensitivity, and nausea can make it difficult for some people to tolerate. Weight loss can include muscle as well as fat. 5 6
• Dosing and duration: Doses are commonly increased gradually; one clinician described getting enough benefit at 1–2 mg weekly, while a trial titrated to 2.4 mg weekly. Weight regain after stopping may occur, so ongoing use may be needed to maintain weight loss. 7 8
• Medical supervision: It should be discussed and managed with a clinician, particularly because nausea can limit tolerability and the appropriate dose varies. 9