L arginine

L-arginine is often discussed alongside L-citrulline due to their roles in the nitric oxide pathway, which affects vasodilation and blood flow. Andrew Huberman has mentioned that although L-arginine itself has low bioavailability, it is important in biological processes. L-citrulline is considered more effective because it converts to L-arginine and stays in the bloodstream longer. This conversion increases nitric oxide levels, which helps with vasodilation and potentially improves growth hormone levels 1 2.

L-citrulline is thus frequently recommended over L-arginine for uses such as enhancing gym performance and increasing blood flow due to its longer-lasting effects and better absorption 2. However, any nitrate pathway agent, like L-citrulline or L-arginine, should be used with caution due to their potential effects on blood pressure and other variables. It’s also mentioned that quality control in the supplement industry can vary, so ensuring the source of the supplements is reputable is important 1.