What peptides does Huberman recommend?

Huberman discusses sermorelin, ipamorelin, tesamorelin, and PT-141 (a melanocyte-stimulating peptide related to the melanocortin system), but he does not present peptides as universal recommendations.

• Sermorelin, ipamorelin, and tesamorelin: These can stimulate growth hormone release and raise IGF-1. Potentially sought effects include fat loss, vitality, and recovery; Huberman also notes sermorelin can deepen sleep, while his own experience included disrupted sleep and little noticeable improvement in recovery or fat loss. 1 2
• PT-141: This activates the melanocortin system and is FDA-approved for low sexual desire in premenopausal women; physicians may prescribe it off-label for men. Nausea, flushing, increased blood pressure, and pigmentation are noted as possible effects. 3
• Tesamorelin approval: It is FDA-approved to reduce abnormal visceral fat in people with HIV-related lipodystrophy. 4
• Caution and sourcing: Huberman emphasizes that peptide effects and risks vary, and recommends physician oversight and prescription-quality sourcing. Gray- and black-market products may contain contaminants such as LPS or may not match their labels. 5