What do other experts say about this?

Other experts, including Dr. Craig Koniver, have shared insights regarding methylene blue's use for health purposes in the episode featuring him on the Huberman Lab. Here are some key points from Dr. Koniver's discussion:

1. Cognitive Enhancement: Dr. Koniver believes methylene blue can serve as a cognitive stimulant, offering improvements in brain function and recall. He notes that many users report significant benefits to their cognitive performance, suggesting nootropic-like effects from its use 1.

2. Dosage Recommendations: He recommends a dose of no more than 10 mg taken in the morning, emphasizing that it is well-absorbed orally, advantageous compared to some other supplements like NAD+ 1.

3. Mitochondrial Function: Methylene blue enhances mitochondrial function by facilitating oxygen uptake in red blood cells. This can lead to improved energy production and cognitive benefits, as it binds to cytochrome c oxidase, a crucial component of the mitochondrial respiratory chain 2.

4. Side Effects: Users should be aware that methylene blue can turn urine blue or green, indicating its metabolic effects, which are an expected result of its action 1.

5. Potential Antiviral Effects: Some claims suggest that methylene blue exhibits antiviral properties, potentially aiding in the efficiency of mitochondrial function, which might explain rapid symptom relief in some conditions 2.

6. Safety Considerations: While it has therapeutic potential, Dr. Koniver caution against excessive doses, especially intravenously, due to potential vein spasms from high doses 1.

Additionally, Dr. David Sinclair, in the episode Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52, raised concerns about the safety of ingesting methylene blue, reiterating the importance of a cautious approach. He noted that while it may have lifespan-extending properties observed in lower organisms, its safety for human use remains a question that requires careful examination 3.

Overall, while there are promising benefits attributed to methylene blue, especially for cognitive function and mitochondrial efficiency, it's essential to approach its use under professional guidance to mitigate potential risks.