Pros and cons of trt

TRT may improve mood, energy, sleep and recovery, but it can substantially reduce sperm production and carries other potential risks. 1

• Potential benefits: People may report better mood and energy, along with improved sleep and recovery. 2
• Fertility: Exogenous testosterone can dramatically reduce sperm production; men who want to conceive should discuss fertility-preserving options with a clinician. 3
• Possible risks: Reported concerns include acne, hair loss, mood changes—including, occasionally, triggering a manic or bipolar episode—and cardiovascular and lipid concerns. The excerpts also mention water retention and bloating with testosterone use, though the physician says these were not seen in his low-dose patients. 4 5
• Prostate cancer: Available longitudinal data discussed in the conversation were described as showing no change in prostate cancer risk with testosterone therapy. 6

These effects and risks depend on the individual and dose, so treatment calls for medical oversight and monitoring. 7