What are the risks of using psilocybin?

Psilocybin use carries several risks, particularly for those with certain mental health predispositions and in unsafe settings. Andrew Huberman outlines key concerns:

1. Psychiatric Risks: Psilocybin is strongly contraindicated for individuals with a history or predisposition to psychotic or bipolar disorders. Even having a close relative with these conditions can be a rule-out criterion for participation in clinical studies, due to the risk of triggering prolonged psychotic episodes 1.

2. Adverse Reactions: There's a risk of experiencing "bad trips," characterized by intense fear, anxiety, or feeling of losing control. These reactions can happen even to psychologically healthy individuals, especially at high doses or in poor settings 2 3.

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     1

     Psilocybin Safety Precautions

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     2

     Psychedelics and Mental Health

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     3

     Psychedelics Explored

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     4

     Safe Psychedelic Journeys

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     5

     Psilocybin Insights

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3. Environmental Safety: Safety concerns necessitate a controlled environment where the person under the influence cannot harm themselves or others. This includes having sober guides present to manage the setting and ensure safety 4.

4. Age Considerations: The majority of research focuses on adults over 25, as younger individuals are still undergoing significant brain development, making them potentially more vulnerable to long-term impacts 1.

5. Legal Status: Psilocybin remains illegal in many places and is usually only decriminalized or permitted in controlled clinical settings, which limits legal access and increases risks associated with illegal use 5.

These insights underscore the importance of careful consideration and professional oversight when considering psilocybin for therapeutic use.