Are there any fungi worth taking as a supplement?

Fungi as supplements, particularly the topic of using psilocybin on a daily basis, were discussed between Andrew Huberman and his guest. They addressed claims suggesting psilocybin could act as a superior alternative to traditional ADHD medications like Adderall or as an antidepressant akin to Prozac. These substances have been taken with the intention to increase focus or improve mood, not necessarily to correct ADHD but possibly to enhance focus and mood for a more enriched life. However, it's important to note that despite these intentions, no peer-reviewed studies with significant credibility have demonstrated benefits in these areas, and proper double-blind research is necessary to validate such uses. For cognitive improvements, studies involving psilocybin microdosing have not produced compelling evidence of its effectiveness 1.

This conversation focuses on psilocybin, which is a psychoactive compound. Discussion on more commonly consumed non-psychoactive fungal supplements like lion's mane or reishi mushrooms would require retrieval of specific references to those in the context of the Huberman Lab podcast data.