What about NAD+?

NAD+ has been discussed on the podcast. It is essential for cellular reactions and energy metabolism, and NR and NMN are commonly discussed precursors used to raise NAD levels. 1

• Evidence for longevity: The human evidence described here does not establish that raising NAD+ extends lifespan; increases in blood levels have been observed, but the discussion distinguishes that from proven benefits to lifespan or other meaningful outcomes. 2
• Andrew Huberman’s experience: He described taking NR and NMN for a subjective increase in energy, not with an expectation of longer life. He also recounted feeling better after NAD infusions, while noting that these experiences were not established by clinical trials. 3 4
• Practical caution: NAD infusions can be uncomfortable, and supplement quality may vary; the discussion recommends third-party testing and consulting a physician about safety. 5 6