Are there studies on methylene blue?

Yes, there are studies and discussions regarding methylene blue in various contexts, including its potential health benefits and effects on cognitive function.

1. Cognitive Enhancement:

   • Methylene blue has been associated with cognitive enhancements, particularly in mitochondrial function, which improves energy production in the brain. Some users report that it helps with memory and overall brain function. In discussions, it was noted that a common dose is around 10 milligrams taken orally, and this dosage is often recommended to be consumed in the morning 1.

2. Antiviral Properties:

   • There's emerging interest in methylene blue's potential antiviral properties. Some anecdotal evidence suggested that it could help alleviate COVID-19 symptoms quickly, although these claims require further scientific scrutiny 2.

3. Safety and Usage:

   • In terms of usage, methylene blue is considered safe in low doses but can have mild side effects, such as turning urine a blue or green color. Higher dosages and incorrect usage can lead to toxicity risks, emphasizing the importance of adhering to recommended guidelines and consulting with healthcare professionals before use 2.

4. Historical Context and Studies:

   • Historically, methylene blue was the first pharmaceutical drug prescribed in the U.S. and has come back into interest for its various applications 2. It has been studied for conditions like carbon monoxide poisoning, where it helps displace carbon monoxide from hemoglobin, enabling better oxygen delivery 2.

5. Mechanism of Action:

   • Methylene blue works by enhancing the function of mitochondria. It aids in the binding of cytochrome c oxidase, which plays a crucial role in the electron transport chain, thus increasing ATP production 2. Also, it has a mild MAO-inhibiting effect, which could prolong the action of neurotransmitters like serotonin 2.

While the discussions surrounding methylene blue are promising, they underscore the need for further clinical studies to validate these benefits and clarify any safety concerns.