Creatine

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Creatine has been discussed in multiple aspects on the , including its effects on depression, brain function, dosing recommendations, and use in treating traumatic brain injuries (TBI).

Creatine and Depression

Creatine supplementation has been shown to augment the response to selective serotonin re-uptake inhibitors (SSRIs) in women with major depressive disorder. Studies suggest that creatine might either lower the needed dose of SSRIs or improve the efficacy of a given dose. Additionally, creatine might induce changes in neural circuits, which could shift mood from negative to positive by enhancing the forebrain phosphocreatine system and interacting with NMDA receptors 1.

Creatine Dosage

The standard dosage for creatine monohydrate is often based on physique; for instance, a standard 5-gram dosage might vary depending on the individual's weight. The exact dosage may range from 3 to 10 grams per day depending on the individual's body weight and physical demands 2.

Creatine and Brain Function

Creatine has significant roles in brain function. It can enhance the function of frontal cortical circuits connected with mood regulation and motivation. This makes it potentially beneficial for mood and even mild forms of depression via the phosphocreatine pathways 3.

Creatine and Depression

Andrew discusses the potential benefits of creatine supplementation for treating depression, including its ability to enhance the response to SSRIs and increase activity in the forebrain phosphocreatine system, which may lead to changes in neural circuits and a shift from negative to positive mood.
Huberman Lab
Understanding & Conquering Depression | Huberman Lab Podcast #34
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Creatine for Traumatic Brain Injury (TBI)

In cases of TBI, higher doses of creatine have shown promising results in reducing symptoms like headaches, dizziness, and fatigue. These effects are attributed to an increase in creatine storage within the brain, which supports cognitive and physical recovery 4.

General Benefits

Besides these specific uses, creatine also benefits muscle performance, cognitive functions, and is involved in energy supply for the brain and muscles. It does not require "loading" as once thought and can be taken daily without specific timing relative to workouts 5.

For more details or to figure the right approach in supplementation for your specific needs, consulting a healthcare provider is advisable.