methylene blue
Sources:
Methylene blue has been discussed on the as a substance with a variety of uses, ranging from historical applications to recent interest in its cognitive benefits. Here's a summary of the discussions:
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Historical and Medical Use: Methylene blue was one of the first pharmaceuticals prescribed in the U.S. and is traditionally used to treat carbon monoxide poisoning by enhancing red blood cells' oxygen carrying capacity. It binds to cytochrome c oxidase in mitochondria, thereby acting as an oxygenator 1.
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Cognitive Benefits: It's gaining attention for potential cognitive enhancement. Some users report improved brain function, particularly in terms of recall and memory, when taken in doses such as 10 mg in the morning. It's compared to a nootropic, aiming to boost cognitive function by affecting the mitochondria 2.
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Practical Considerations: Methylene blue can stain the mouth and change urine color to green or blue, providing a visual indicator of its use and metabolic effects. It's suggested that issues such as no urine color change might point to mitochondrial inefficiencies 3.
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Balance of Safety and Use: While it's not on some banned lists for sports, potential users are advised to check local regulations. Over-the-counter and prescription forms exist, with some clinicians advising it as a mitochondrial "insurance policy," particularly due to its mild MAOI effects, allowing neurotransmitters like serotonin to linger longer 3.
Overall, while methylene blue shows potential for various uses, caution is recommended regarding dosage and application, and more research is required to fully understand its effects and safety in regular use.
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