• What biomarkers does Peter Attia emphasize?

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    Dr. Peter Attia emphasizes various biomarkers to assess healthspan and lifespan, focusing on functional tests and specific blood markers. Here are some key biomarkers and their relevance as he discusses:

    Blood Biomarkers:

    • Apolipoprotein B (ApoB): Highly important for assessing the risk of atherosclerosis and cardiovascular diseases. It is a critical marker for evaluating lipoprotein levels and endothelial health 1.
    • Statins C: Preferred over creatinine for accurately measuring kidney function. Maintaining optimal kidney health is crucial for longevity 2.
    • Inflammation Markers: These include various markers indicating endothelial health, which are important for both cardiovascular and cognitive health 1.

    Functional Tests:

    Cognitive and Dementia-Related Biomarkers:

    • Genetic Testing for Alzheimer's: Includes comprehensive genetic markers beyond APOE to stratify risk for Alzheimer's and other dementias 1.
    • Serum Amyloid Markers: Used for tracking and managing Alzheimer's disease, although their efficacy is still under research 4.

    Hormone Levels:

    • Insulin Sensitivity and Resistance: Important for identifying risks associated with type 2 diabetes and metabolic health. This includes monitoring glucose levels and insulin response 5.

    Additional Considerations:

    • Emotional Well-being: While not a traditional biomarker, emotional health is highlighted as a crucial component of overall well-being and longevity, impacting life quality and functionality 3.

    These biomarkers and functional tests provide a comprehensive approach to evaluating and improving healthspan and lifespan, emphasizing both measurable lab results and practical assessments of physical and cognitive function.

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