What biomarkers does Peter Attia emphasize?
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Dr. Peter Attia emphasizes various biomarkers to assess healthspan and lifespan, focusing on functional tests and specific blood markers. Here are some key biomarkers and their relevance as he discusses:
Blood Biomarkers:
- Apolipoprotein B (ApoB): Highly important for assessing the risk of atherosclerosis and cardiovascular diseases. It is a critical marker for evaluating lipoprotein levels and endothelial health 1.
- Statins C: Preferred over creatinine for accurately measuring kidney function. Maintaining optimal kidney health is crucial for longevity 2.
- Inflammation Markers: These include various markers indicating endothelial health, which are important for both cardiovascular and cognitive health 1.
Functional Tests:
- DEXA Scan: Used to measure body composition, especially important for assessing muscle mass and fat distribution 3.
- VO2 Max Testing: Critical for evaluating cardiovascular fitness and maximal aerobic capacity 3.
- CPET (Cardiopulmonary Exercise Testing): Provides insight into cardiovascular and respiratory function during exercise 3.
- Lactate Testing and Fat Oxidation: These tests help in understanding metabolic health and efficiency 3.
Cognitive and Dementia-Related Biomarkers:
- Genetic Testing for Alzheimer's: Includes comprehensive genetic markers beyond APOE to stratify risk for Alzheimer's and other dementias 1.
- Serum Amyloid Markers: Used for tracking and managing Alzheimer's disease, although their efficacy is still under research 4.
Hormone Levels:
- Insulin Sensitivity and Resistance: Important for identifying risks associated with type 2 diabetes and metabolic health. This includes monitoring glucose levels and insulin response 5.
Additional Considerations:
- Emotional Well-being: While not a traditional biomarker, emotional health is highlighted as a crucial component of overall well-being and longevity, impacting life quality and functionality 3.
These biomarkers and functional tests provide a comprehensive approach to evaluating and improving healthspan and lifespan, emphasizing both measurable lab results and practical assessments of physical and cognitive function.
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