rapamycin

Rapamycin is a drug under scientific investigation with potential applications in extending lifespan and enhancing immunity. Andrew Huberman discusses its implications and ongoing research.

Key Points:

1. Biological Mechanism:
   • Rapamycin targets mTOR (mammalian Target of Rapamycin), a key protein involved in cell growth and aging. It is traditionally used as an anti-cancer and immunosuppressive drug but is also studied for its potential to extend lifespan 1 2.
2. Research and Experts:
   • Dr. Matt Kaeberlein is studying rapamycin's effects on lifespan, including its application in dogs.
   • Peter Attia emphasizes its potential but notes the importance of personal medical context and the timing of future studies, such as the 2026 dog aging study 1 3.
     
     1
     Rapamycin Insights
     00:21:18
     
     2
     Rapamycin Insights
     01:41:23
     
     3
     Lifespan Extension Insights
     00:20:23
     
     4
     Aging and Molecules
     00:17:22
     
     5
     Lifespan Extension Insights
     01:13:21
3. Clinical Use and Personal Experiences:
   • Rapamycin has shown effectiveness across multiple species in extending lifespan, sharing its success in both mice and higher-order mammals 4 5.
   • Dr. Huberman himself does not take it currently, citing insufficient personal data and potential side effects.
   • Dr. Attia takes a specific dosage (8 mg weekly) but mentions having to manage side effects such as mouth sores 4.

Considerations:

• Rapamycin, while promising, still carries risks and is associated with side effects like immune modulation. Further research is needed to firmly establish its benefits and safety for human longevity 1 2.
• The foundational elements for a long and healthy life, such as quality sleep and a healthy lifestyle, remain paramount despite the potential supplemental benefits of rapamycin 1.

For those interested in rapamycin, keeping up with emerging studies and consulting healthcare professionals is crucial to make well-informed decisions.